Database : HANSEN Search on : MYCOBACTERIUM LEPRAE/QUIM [Subject descriptor] References found : 17 [refine] Displaying: 1 .. 17   in format [Detailed]

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Id: 19364 Author: Suneetha, Lavanya M; Vardhini, Deena; Suneetha, Sujai; Balasubramanian, A. S; Job, C. K; Scollard, David. Title: Biochemical aspects of mycobacterium leprae binding proteins: a review of their role in pathogenesis. Source: Int. J. Lepr;69(4):341-348, Dec., 2001. tab. Descriptors: Mycobacterium leprae/quim Mycobacterium leprae/genet Mycobacterium leprae/imunol Proteínas/quim Proteínas/sint quim Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2001/pdf/v69n4/v69n4edt.pdf / en Location: BR191.1

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Id: 18910 Author: Zabary-Simon, P. Title: Método de coloração metacromática do "Mycobacterium leprae" / Metachromatic staining method of "Mycobacterium leprae" Source: Rev. bras. Leprol;15(1):25-27, mar. 1947. . Descriptors: Mycobacterium leprae/quim Mycobacterium leprae/imunol Mycobacterium leprae/fisiol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/1947/PDF/v15n1/v15n1a04.pdf / pt Location: BR191.1

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Id: 18506 Author: Bakker, Mirjam Title: Epidemiology and prevention of leprosy: a cohort study in Indonesia^ien ..- Source: s.l; The Netherlands Leprosy Relief; 2005. 165 p. ^bilus, ^bmapas, ^btab, ^bgraf. Abstract: Leprosy is an infectious disease caused by Mycobacterium leprae, a bacterium which primarily affects the nerves and skin. Worldwide 513,798 new patients were detected in 2003. Trend analysis showed that the new case detection rate did not decline between 1985 and 2000. Leprosy diagnosis is aminly based on the presence of skin lesions, loss of sensitivity and thickened nerves. The clinical pattern varies widely between patients due to a different level of celular immunity that an infected person mounts to the infection. For treatment purposes patients are divided into paucibacillary (PB) and multibacillary (MB) patients. Effective treatment against leprosy is available (chapter 1). In the last five decades cohort studies have investigated risk factors for developing leprosy. Most of these studies were conducted among contacts of leprosy patients and a few were population-based. Risk factors for developing leprosy were grouped into three levels: (1) individual level; (2) household and community levels; (3) meso/macro levels (chapter 1). As leprosy case detections rates did not decline in the last 15 years despite effective multi-drug treatment, new approaches and strategies to definitely eliminate leprosy as a public health problem are required. Four research questions were addressed in this thesis: "Which patients transmit leprosy?", "What are risk factors for developing leprosy?", "Can rifampicin, used as chemoprophylaxis, prevent leprosy?" and "How can chemoprophylaxis be most efficiently implemented?". All studies presented in this thesis were preformed in the same study area, five geographically isolated islands in the Flores Sea, Indonesia, and are part of still continuing population-based cohort study. Chaper 2 mainly serves as background information on the leprosy epidemic in the study area. It describes how an enormous load of backlog patients existed on these islands, with only irregular leprosy control before 2000. The overvall new case detection ra...(AU)^ien. Descriptors: HANSENIASE/diag HANSENIASE/epidemiol HANSENIASE/prev INDONESIA/epidemiol MYCOBACTERIUM LEPRAE/quim MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/fisiol Limits: ESTUDO COMPARATIVO Location: BR191.1; WC335.300, B179e

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Id: 18389 Author: Rambukkana, Anura Title: Mycobacterium leprae-induced demyelination: a model for early nerve degeneration ..- Source: s.l; s.n; 2004. 7 p. ilus. Abstract: The molecular events that occur at the early phase of many demyelinating neurodegenerative diseases are unknown. A recent demonstratation of rapid demyelination and axonal injury induced by Mycobacterium leprae provides a model for elucidating the molecular events of early nerve degeneration which might be common to neurodegenerative diseases of both infectious origin and unknown etiology. The identification of the M. leprae-targeted Schwann cell receptor, dystroglycan, and its associated molecules in myelination, demyelination and axonal functions suggests a role for these molecules in early nerve degeneration (AU). Descriptors: DOENCAS DESMIELINIZANTES/etiol DOENCAS DESMIELINIZANTES/imunol DOENCAS DESMIELINIZANTES/microbiol DOENCAS DESMIELINIZANTES/patol MYCOBACTERIUM LEPRAE/quim MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/patogen - DEGENERACAO NEURAL/etiol  DEGENERACAO NEURAL/patol  HANSENIASE/compl  HANSENIASE/imunol  HANSENIASE/microbiol  HANSENIASE/patol Limits: HUMANO Location: BR191.1; 09300/s

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Id: 18218 Author: Britton, Warwick J; Lockwood, Diana N. J Title: Leprosy ..- Source: s.l; s.n; 2004. 11 p. ilus, tab, graf. Abstract: Leprosy remains an important health problem wordwide. The disease in caused by a chronic granulomatous infection of the skin and peripheral nerves with Mycobacterium leprae. The clinical range from tuberculoid to lepromatous leprosy is a result of variation in the cellular immune response to the mycobacterium. The resulting impairment of nerve fuinction causes be disabilities associated with leprosy. This review summarises recent advances in understanding of the biology of leprosy, clinical features of the disease, the current diagnostic criteria, and the new approaches to treatment of the infection and the immune-mediated complications. Supervesed multi-drug therapy (MDT) for fixed durations is highly effective for all forms of the disease. The widespread implemantation of MDT has been associated with a fall in the prevalence of the leprosy but as yet no reduction in the case-detection rate globally. Thus, leprosy control activities must be maintained for decades to interrupt transmission of infection (AU). Descriptors: HANSENIASE/compl HANSENIASE/diag HANSENIASE/epidemiol HANSENIASE/prev HANSENIASE/terap HANSENIASE/transm MYCOBACTERIUM LEPRAE/quim MYCOBACTERIUM LEPRAE/citol MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM LEPRAE/patogen QUIMIOTERAPIA COMBINADA - NEURITE/etiol  NEURITE/imunol  NEURITE/microbiol  EDUCACAO EM SAUDE/tend  RELACOES HOSPEDEIRO-PARASITA/imunol Limits: HUMANO Location: BR191.1; 09193/s

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Id: 18059 Author: Amador, Maria do Perpetuo Socorro Title: Soroprevalencia para hanseniase em areas endemicas do estado do Para Soroprevalence for leprosy in endemic areas of the state of Para- Source: Belem; s.n; 2004. 126 p. ilus, tab, graf. Thesis: Present for Universidade Federal do Para presented for the degree Mestre. Abstract: Analisou-se a prevalencia de anticoepos IgM utilizando teste sorologico e antigeno especifico Glicolipidio Fenolico I (PGL-I) do Mycobacterium leprae, por meio do teste rapido ML Dipstick em 1611 individuos sadios categorizados em contatos de pacientes hansenicos intradomiciliares e comunitarios, residentes em cinco municipios endemicos para hanseniase. Realizou-se estudo tranversal pela analise do banco de dados do laboratorio de hanseniase, Instituto Evandro Chagas. O estudo estendeu-se de março a dezembro de 1998, com reavaliaçoes anuais ate dezembro de 2002, no qual, os municipios selecionados-Curinopolis, Eldorado do Carajas, Xinguara, Rondon do Para e Dom Eliseu - apresentaram taxas de prevalencia em hanseniase maiores que 20 em cada 10.000 hab. e detecçao de casos novos maiores que quatro em cada 10.000 hab. A idade variou de 2 a 90 anos, devido ao fato de que a doença em areas de alta endemicidade possibilita o diagnostico de crianças. Estudou-se 957 mulheres (957/1611-59.4 por cento), 654 homens (654/1611-40.6 por cento) e observou-se predominancia de soropositividade entre as mulheres na faixa etaria entre 21 e 50 anos, 62.81 por cento contra 53.97 por cento nos homens. A analise foi realizada nos bancos de dados D-BASE, EPI-INFO 6.4 e 2002, BIOESTAT 3.0 e SINAM, existentes no Instituto Evandro Chagas e Secretaria Estadual de Saude do Para...(AU). Descriptors: HANSENIASE/epidemiol HANSENIASE/imunol HANSENIASE/fisiopatol HANSENIASE/reabil MYCOBACTERIUM LEPRAE/quim MYCOBACTERIUM LEPRAE/citol MYCOBACTERIUM LEPRAE/genet MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM LEPRAE/fisiol MYCOBACTERIUM LEPRAE/patogen - IMUNOGLOBULINA M/anal  IMUNOGLOBULINA M/quim  IMUNOGLOBULINA M/uso diag Limits: RELATO DE CASO ESTUDO COMPARATIVO HUMANO Location: BR191.1; WC335.300.10, A11s

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Id: 17813 Author: Floch, Herve Alexandre. Title: About Bioresistance, Comparative Chemoresistance and Sulfono Resistance of M. leprae. Source: Hansen. int;14(1):46-49, Jun. 1989. . Descriptors: MYCOBACTERIUM LEPRAE/quim MYCOBACTERIUM LEPRAE/fisiol Limits: ESTUDO COMPARATIVO Location: BR191.1

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Id: 15285 Author: Ota, Masao; Sato, Saburo. Title: Cultivation of leprosy bacilli and of the tubercle bacillus from leprosy tissues. Source: Int. J. Lepr;2(2):175-192, Apr.-July 1934. . Descriptors: MYCOBACTERIUM LEPRAE/quim MYCOBACTERIUM LEPRAE/isol MYCOBACTERIUM LEPRAE/patogen Location: BR191.1

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Id: 13864 Author: Maestre Mesa, Jorge Luis; González Segredo, Ángel. Title: Ensayo de la prueba cutánea con el antígeno soluble del Mycobacterium leprae en un grupo de riesco. Source: Fontilles - Revista de Leprología;18(1):55-62, Ene.-Abr. 1991. tab, graf. Abstract: Se realizó un estudio mediante pruebas cutáneas con antígeno soluble de M. leprae (ASMI y derivado purificado de porteínas (PPD) en 192 convivientes de pacientes de lepra multibacilar, con el objetivo de evaluar la utilidad del método para identificación de indivíduos presumiblemente infectados com M. leprae. Todos ellos residían en el municipio Guantánamo, que es el área de más alta prevalencia de lepra en Cuba. El tamaño medio de la reacción fue 5'03 mm. mientras que en los grupos de control utilizado fue 0 mm. en pacientes lepromatosos, 18'62 mm. en pacientes tuberculoide, 2'75 mm. en pacientes tuberculosis pulmonar y 1'72 en individuos sanos. El criterio de positividad para ambas pruebas fue de 6 mm. Se observó que la prueba cutánea con ASMI puede der útil para al conducción de estudios epidemiológicos ya que, entre los convivientes positivos, el tamaño de la reacción fue significativamente mayor que el observado con el PPD. (AU). Descriptors: HANSENIASE MYCOBACTERIUM LEPRAE/quim MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM LEPRAE/metab ANTIGENOS/imunol Location: BR191.1

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Id: 13783 Author: Fereira, Ennio; Barroso, César; Fernández, Romer; Ilukevich, Alexis. Title: Sobre algunas características antigenicas de micobacterias aisladas en cultivo a partir de material lepromatoso: viraje de Mitsuda en pacientes L.L. y contactos. Source: Fontilles - Revista de Leprología;10(5):471-483, May.-Ago. 1976. ilus, tab. Abstract: Basándose en el concepto de que "vacunar contra la lepra no es inocular B.C.G., sino comproblar que Mitsuda ha virado", los autores exponen sus experiencias con los 4 siguientes grupos de sujetos. Grupo I: 28 pacientes lepromatosos (LL), Mitsuda negativos. Grupo II: 10 pacientes tuberculoides (LT), Mitsuda positivos. Grupo III: 7 contactos (niños de 7 a 14 años de edad), Mitsuda negativos. Grupo IV: 26 contactos (niños de 6 a 15 años de edad), Mitsuda negativos. A los integrantes de los primeros 3 grupos mencionados se les aplicó el Antígeno Zulia, constituido por una suspensión bacilar de micobacterias aisladas en cultivo a partir de pacientes lepromatosos (0'1 ml. por vía intradérmica), y simultáneamente, o de 1 a 3 meses después, se les sometió a la prueba clásica de Mitsuda. A los contactos reunidos en el Grupo IV y ensayados con fines comparativos, se les aplicó B.C.G., en substitución del Antígeno Zulia. Estos ensayos demostraron que en 24 de los 28 pacientes L.L. (Grupo I), y en 5 de los 7 contactos (Grupo III, todos inicialmente Mitsuda negativos, se presentó un inminente viraje de los valores inmunológicos, fenómeno inducido por la aplicación del Antígeno Zulia y manifesto por la aparición de reacciones positivas a la lepromina clásica. Por otra parte se hizo notorio que de los 26 contactos vacunados con la única dosis de B.C.G., solamente 14 habían virado su Mitsuda a positivo. Los autores suponen que el "virage" mencionado es una expresión de mecanismos defensivos en individuos en los cuales éstos estaban bloqueados (probablemente por desaparisión de la capacidad linfocitaria de producir el factor de migración de macrófagos) y señalan que el Antígeno Zulia se destaca ampliamente por su capacidad de convertir a los sujetos Mitsuda negativos en sujetos Mitsuda positivos. (AU). Descriptors: HANSENIASE/quimioter MYCOBACTERIUM LEPRAE/quim MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM LEPRAE/isol ANTIGENO DE MITSUDA/isol Location: BR191.1

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Id: 11472 Author: Dockrell, Hazel M; Brahmbhatt, Shweta; Robertson, Brian D; Britton, Sven; Fruth, Uli; Gebre, Negussie; Hunegnaw, Mesfin; Hussain, Rabia; Manandhar, Rakesh; Murillo, Luis; Pessolani, Maria Cristina V; Roche, Paul; Salgado, Jorge L; Sampaio, Elizabeth; Shahid, Firdaus; Thole, Jelle E. R; Young, Douglas B Title: A postgenomic approach to identification of mycobacterium leprae-specific peptides as T-cell reagents ..- Source: s.l; s.n; 2000. 10 p. tab, graf. Descriptors: HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS EPITOPOS DE LINFOCITO T EPITOPOS DE LINFOCITO T GENOMA BACTERIANO ANTIGENOS HLA-DR ANTIGENOS HLA-DR TRANSFORMAÇAO LINFOCITICA DADOS DE SEQUENCIA MOLECULAR PEPTIDIOS PEPTIDIOS ESPECIFICIDADE DE ESPÉCIES LINFOCITOS T Location: BR191.1; 08351/s

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Id: 10206 Author: Brennan, Patrick J; Chatterjee, Delphi; Fujiwara, Tsuyoshi; Cho, Sang-Nae Title: Leprosy-specific neoglycoconjugates: synthesis and application to serodiagnosis of leprosy ..- Source: s.l; s.n; 1994. 11 p. ilus, tab. Descriptors: ANTIGENOS DE BACTÉRIAS SEQUENCIA DE CARBOIDRATOS ELISA GLICOCONJUGADOS GLICOCONJUGADOS GLICOLIPIDIOS GLICOLIPIDIOS IGM HANSENIASE HANSENIASE HANSENIASE DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM LEPRAE Location: BR191.1; 06980/s

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Id: 10105 Author: Moura, A. C. N; Modolell, M; Mariano, M Title: Down-regulatory effect of Mycobacterium leprae cell wall lipids on phagocytosis, oxidative respiratory burst and tumour cell killing by mouse bone marrow derived macrophages ..- Source: s.l; s.n; 1997. 6 p. ilus, tab, graf. Descriptors: PAREDE CELULAR DEPRESSAO QUIMICA HANSENIASE LIPIDIOS LIPIDIOS LIPOSSOMOS ATIVAÇAO DE MACROFAGOS MACROFAGOS MACROFAGOS MACROFAGOS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS BALB C CAMUNDONGOS ENDOGAMICOS C57BL MYCOBACTERIUM LEPRAE FAGOCITOSE EXPLOSAO RESPIRATORIA SUPEROXIDOS CELULAS DA MEDULA OSSEA/*DE/PH CELULAS CULTIVADAS Limits: ANIMAL Location: BR191.1; 07046/s

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Id: 10093 Author: Deshpande, Rajashri G; Khan, Mahfuz B; Bhat, Deepashree A; Navalkar, R. G Title: Immunoaffinity chromatographic isolation of a high molecular weight seroreactive protein from Mycobacterium leprae cell sonicate ..- Source: s.l; s.n; 1995. 7 p. ilus, tab. Descriptors: HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM PARATUBERCULOSIS ANTICORPOS MONOCLONAIS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS CITOCROMO B FERRITINA DADOS DE SEQUENCIA MOLECULAR PESO MOLECULAR HOMOLOGIA DE SEQUENCIA DE AMINOACIDOS Limits: ANIMAL HUMANO COELHOS Location: BR191.1; 07152/s

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Id: 10081 Author: Dhople, Arvind M Title: Factors influencing the in vitro growth of Mycobacterium leprae: effect of inoculum ..- Source: s.l; s.n; 1998. 11 p. tab. Descriptors: HANSENIASE HANSENIASE ADENOSINA TRIFOSFATO RADIOISOTOPOS DE COBALTO MEIOS DE CULTURA FIGADO FIGADO BAÇO BAÇO TIMIDINA MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE Location: BR191.1; 07140/s

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Id: 9681 Author: Adams, E; Britton, W. J; Morgan, A; Goodsall, A. L; Basten, A Title: Identification of human T cell epitopes in the Mycobacterium leprae heat shock protein 70-kD antigen ..- Source: s.l; s.n; 1993. 7 p. ilus, tab. Descriptors: SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTÉRIAS VACINA BCG EPITOPOS PROTEINAS DO CHOQUE TÉRMICO PROTEINAS DO CHOQUE TÉRMICO HANSENIASE TRANSFORMAÇAO LINFOCITICA DADOS DE SEQUENCIA MOLECULAR PESO MOLECULAR MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS MYCOBACTERIUM TUBERCULOSIS PEPTIDIOS PEPTIDIOS PEPTIDIOS PROTEINAS RECOMBINANTES HOMOLOGIA DE SEQUENCIA DE AMINOACIDOS LINFOCITOS T TUBERCULOSE PULMONAR Location: BR191.1; 06669/s

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Id: 9414 Author: Sharma, Vinod K; Kaur, Surrinder; Kaur, Inderjeet; Thakur, Mridula; Vaishnavi, Chetana; Kohli, Manjula; Ganguly, Nirmal K Title: Adenosine triphosphate content of Mycobaterium leprae by percoll buoyant density centrifugation ..- Source: s.l; s.n; 1992. 3 p. tab. Descriptors: ADENOSINA TRIFOSFATO CENTRIFUGAÇAO COM GRADIENTE DE CONCENTRAÇAO HANSENIASE DIMORFA HANSENIASE LEPROMATOSA MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE POVIDONA DIOXIDO DE SILICIO Location: BR191.1; 06388/s

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